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成果報告:横断研究の論文

  1. Nanri H, Nishida Y, Nakamura K, Tanaka K, Naito M, Yin G, Hamajima N, Takashima N, Suzuki S, Nindita Y, Kohno M, Uemura H, Koyama T, Hosono S, Mikami H, Kubo M, Tanaka H, for the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group.. Associations between dietary patterns, ADRbeta2 Gln27Glu and ADRbeta3 Trp64Arg with regard to serum triglyceride levels: J-MICC Study. .Nutrients 2016; 8: 545.

    →「日常的な食事パターンと肥満関連遺伝子多型が血液中の中性脂肪値に与える影響」

  2. Nishida Y, Hara M, Sakamoto T, Shinchi K, Kawai S, Naito M, Hamajima N, Kadota A, Suzuki S, Ibusuki R, Hirata A, Yamaguchi M, Kuriyama N, Oze I, Mikami H, Kubo M, Tanaka H for the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group.. Influence of cigarette smoking and inflammatory gene polymorphisms on glycated hemoglobin in the Japanese general population. .Preventive Medicine Reports. 2016;3:288-95..

    →「喫煙と炎症性サイトカイン遺伝子多型が血糖指標ヘモグロビンA1c に及ぼす影響」

  3. Uemura H, Katsuura-Kamano S, Yamaguchi M, Arisawa K, Hamajima N, Hishida A, Kawai S, Oze I, Shinchi K, Takashima N, Suzuki S, Nakahata N, Mikami H, Ohnaka K, Kuriyama N, Kubo M, Tanaka H; Japan Multi-institutional Collaborative Cohort (J-MICC) Study Group.. A variant of the CLOCK gene and related haplotypes are associated with the prevalence of type 2 diabetes in the Japanese population. .J Diabetes. 2016; 8: 667-676.

    →「時計遺伝子の遺伝子多型と2型糖尿病」

  4. Yin G, Naito M, Wakai K, Morita E, Kawai S, Hamajima N, Suzuki S, Kita Y, Takezaki T, Tanaka K, Morita M, Uemura H, Ozaki E, Hosono S, Mikami H, Kubo M, Tanaka H, for The Japan Multi-institutional Collaborative Cohort (J-MICC) Study Group.. ALDH2 polymorphism is associated with fasting blood glucose through alcohol consumption in Japanese men. .Nagoya J Med Sci. 2016;78:183-193..

    →「遺伝子多型と空腹時血糖値」

  5. Hosono S, Ito H, Oze I, Higaki Y, Morita E, Takashima N, Suzuki S, Shimatani K, Mikami H, Ohnaka K, Ozaki E, Katsuura-Kamano S, Kubo M, Nagata C, Naito M, Hamajima N, Tanaka H; Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group.. Polymorphisms in CYP19A1, HSD17B1 and HSD17B2 genes and serum sex hormone level among postmenopausal Japanese women. .Maturitas. 2015; 82: 394-401.

    →「閉経女性の女性ホルモン濃度に影響する遺伝子型」

  6. Koyama T, Matsui D, Kuriyama N, Ozaki E, Tanaka K, Oze I, Hamajima N, Wakai K, Okada R, Arisawa K, Mikami H, Shimatani K, Hirata A, Takashima N, Suzuki S, Nagata C, Kubo M, Tanaka H.. Genetic variants of SLC17A1 are associated with cholesterol homeostasis and hyperhomocysteinemia in Japanese men. .Scientific Reports 2015; 5: 15888..

    →「日本人男性におけるSLC17A1遺伝子多型は、コレステロール恒常性と高ホモシステイン血症に関係する」

  7. Sugimoto Y, Wakai K, Nakagawa H, Suma S, Sasakabe T, Sakamoto T, Takashima N, Suzuki S, Ogawa S, Ohnaka K, Kuriyama N, Arisawa K, Mikami H, Kubo M, Hosono S, Hamajima N, Tanaka H; J-MICC Study Group.. Associations between polymorphisms of interleukin-6 and related cytokine genes and serum liver damage markers: a cross-sectional study in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. .Gene. 2015;557:158-162..

    →「肝障害に影響する遺伝子型」

  8. Yamaguchi M, Uemura H, Arisawa K, Katsuura-Kamano S, Hamajima N, Hishida A, Suma S, Oze I, Nakamura K, Takashima N, Suzuki S, Ibusuki R, Mikami H, Ohnaka K, Kuriyama N, Kubo M, Tanaka H, the Japan Multi-institutional Collaborative Cohort (J-MICC) Study Group.. Association between brain-muscle-ARNT-like protein-2 (BMAL2) gene polymorphism and type 2 diabetes mellitus in obese Japanese individuals: A cross-sectional analysis of the Japan Multi-Institutional Collaborative Cohort Study. .Diabetes Res Clin Pract. 2015;110:301-308..

    →「BMAL2遺伝子多型は2型糖尿病の罹りやすさに関連する」

  9. Hara M, Nakamura K, Nanri H, Nishida Y, Hishida A, Kawai S, Hamajima N, Kita Y, Suzuki S, Mantjoro EM, Ohnaka K, Uemura H, Matsui D, Oze I, Mikami H, Kubo M, Tanaka H. Associations between hOGG1 Ser326Cys polymorphism and increased body mass index and fasting glucose level in the Japanese general population .J Epidemiol. 2014;24:379-384..

    →「hOGG1遺伝子多型と肥満との関連は、居住地域の影響を受ける」

  10. Hishida A, Takashima N, Turin T, Kawai S, Wakai K, Hamajima N, Hosono S, Nishida Y, Suzuki S, Nakahata N, Mikami H, Ohnaka K, Matsui D, Katsuura-Kamano S, Kubo M, Tanaka H, Kita Y. GCK, GCKR polymorphisms and risk of chronic kidney disease in Japanese: cross-sectional data from the J-MICC Study .J Nephrol. 2014;27:143-149..

    →「日本人の慢性腎臓病の罹りやすさは、糖質の代謝に関わるある遺伝子と、タバコとの複合的作用によって決まる可能性がある」

  11. Hishida A, Wakai K, Naito M, Suma S, Sasakabe T, Hamajima N, Hosono S, Horita M, Turin TC, Suzuki S, Kairupan TS, Mikami H, Ohnaka K, Watanabe I, Uemura H, Kubo M, Tanaka H; J-MICC Study Group.. Polymorphisms of genes involved in lipid metabolism and risk of chronic kidney disease in Japanese – cross-sectional data from the J-MICC study. .Lipids Health Dis. 2014;13:162..

    →「慢性腎臓病の罹りやすさと脂質代謝遺伝子」

  12. Katsuura-Kamano S, Uemura H, Arisawa K, Yamaguchi M, Hamajima N, Wakai K, Okada R, Suzuki S, Taguchi N, Kita Y, Ohnaka K, Kairupan TS, Matsui D, Oze I, Mikami H, Kubo M, Tanaka H. A polymorphism near MC4R gene (rs17782313) is associated with serum triglyceride levels in the general Japanese population: the J-MICC Study .Endocrine. 2014;47:81-89..

    →「血液中の中性脂肪値に関連する遺伝子多型」

  13. Hishida A, Okada R, Naito M, Morita E, Wakai K, Hamajima N, Hosono S, Nanri H, Turin TC, Suzuki S, Kuwabara K, Mikami H, Budhathoki S, Watanabe I, Arisawa K, Kubo M, Tanaka H. Polymorphism in genes encoding antioxidant enzymes (SOD2, CAT, GPx, TXNRD, SEPP1, SEP15 and SELS) and risk of chronic kidney disease in Japanese – cross-sectional data from the J-MICC study .J Clin Biochem Nutr. 2013;53:15-20.

    →「日本人の慢性腎臓病の発症に関連する遺伝体質の1つが新たに判明した」

  14. Hishida A, Okada R, Yin G, Naito M, Wakai K, Hosono S, Nakamura K, Turin TC, Suzuki S, Niimura H, Mikami H, Otonari J, Kuriyama N, Katsuura S, Kubo M, Tanaka H, Hamajima N. MTHFR, MTR, MTRR polymorphisms and risk of chronic kidney disease in Japanese: cross-sectional data from the J-MICC study .Int Urol Nephrol. 2013;45:1613-1620..

    →「葉酸の代謝に関わる遺伝子の違いは、慢性腎臓病の発症に関連する可能性が」

  15. Hishida A, Morita E, Naito M, Okada R, Wakai K, Matsuo K, Nakamura K, Takashima N, Suzuki S, Takezaki T, Mikami H, Ohnaka K, Watanabe Y, Uemura H, Kubo M, Tanaka H, Hamajima N. Associations of apolipoprotein A5 (APOA5), glucokinase (GCK) and glucokinase regulatory protein (GCKR) polymorphisms and lifestyle factors with the risk of dyslipidemia and dysglycemia in Japanese – a cross-sectional data from the J-MICC Study .Endocr J. 2012;59:589-99.

    →「脂質代謝異常症がおこりやすい遺伝子多型」

  16. Hiyoshi M, Uemura H, Arisawa K, Nakamoto M, Hishida A, Okada R, Matsuo K, Kita Y, Niimura H, Kuriyama N, Nanri H, Ohnaka K, Suzuki S, Mikami H, Kubo M, Tanaka H, Hamajima N; J-MICC Study Group. Association between the catechol-O-methyltransferase (rs4680: Val158Met) polymorphism and serum alanine aminotransferase activity .Gene. 2012;496:97-102.

    →「肝機能に関わる遺伝子多型」

  17. Nishiyama T, Kishino H, Suzuki S, Ando R, Niimura H, Uemura H, Horita M, Ohnaka K, Kuriyama N, Mikami H, Takashima N, Mastuo K, Guang Y, Wakai K, Hamajima N, Tanaka H; J-MICC Study Group. Detailed analysis of Japanese population substructure with a focus on the southwest islands of Japan .PLoS One. 2012;7:e35000.

    →「現代日本人はどうやって生じたか」

  18. Uemura H, Hiyoshia M, Arisawa K, Yamaguchi M, Naito M, Kawai S, Hamajima N, Matsuo K, Taguchi N, Takashima N, Suzuki S, Hirasada K, Mikami H, Ohnaka K, Yoshikawa A, Kubo M, Tanaka H. Gene variants in PPARD and PPARGC1A are associated with timing of natural menopause in the general Japanese population .Maturitas 2012;71:369-375.

    →「閉経年齢に関わる遺伝子多型」

  19. Wakai K, Hamajima N, Okada R, Naito M, Morita E, Hishida A, Kawai S, Nishio K, Yin G, Asai Y, Matsuo K, Hosono S, Ito H, Watanabe M, Kawase T, Suzuki T, Tajima K, Tanaka K, Higaki Y, Hara M, Imaizumi T, Taguchi N, Nakamura K, Nanri H, Sakamoto T, Horita M, Shinchi K, Kita Y, Turin TC, Rumana N, Matsui K, Miura K, Ueshima H, Takashima N, Nakamura Y, Suzuki S, Ando R, Hosono A, Imaeda N, Shibata K, Goto C, Hattori N, Fukatsu M, Yamada T, Tokudome S, Takezaki T, Niimura H, Hirasada K, Nakamura A, Tatebo M, Ogawa S, Tsunematsu N, Chiba S, Mikami H, Kono S, Ohnaka K, Takayanagi R, Watanabe Y, Ozaki E, Shigeta M, Kuriyama N, Yoshikawa A, Matsui D, Watanabe I, Inoue K, Ozasa K, Mitani S, Arisawa K, Uemura H, Hiyoshi M, Takami H, Yamaguchi M, Nakamoto M, Takeda H, Kubo M, and Tanaka H for the J-MICC Study Group. Profile of Participants and Genotype Distributions of 108 Polymorphisms in a Cross-Sectional Study of Associations of Genotypes With Lifestyle and Clinical Factors: A Project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study .J Epidemiol. 2011;21:223-235..

    →「お酒への強さに関係する遺伝子にも地域差」

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